Methuselah Gene

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Methuselah Gene

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Dark Willow

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Studies

Methuselah Gene

post #1

01-19-2016 at 09:47 am

Some shorter people possess a rare genetic mutation, known as the "Methuselah gene," that seems to extend their life spans. This defect affects the way their cells use the hormone insulinlike growth factor 1. IGF1 plays a key role in childhood growth—and, more controversially, is touted by athletes and anti-aging proponents as a miracle cure that can help bulk up muscle, inhibit programmed cell death, and reduce body fat.

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Mr Dixon

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Re: Methuselah Gene

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01-19-2016 at 10:00 am

I always found it interesting that both short men and women tend to pack on muscle easier as well as hold fat differently as well. Also, shorter people tend to age better if you ask me.

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Dale

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Re: Methuselah Gene

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01-19-2016 at 10:40 am

How do you know if you have this gene? Clearly not all short people do...

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Re: Methuselah Gene

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01-19-2016 at 10:48 am

This is interesting...

"IGF1 is well known among longevity genes. A regulator of growth and differentiation, it has a strong effect on body size, accounting for size extremes in dogs, for example. Animals fed restricted calorie diets live longer and show lower levels of IGF1. (Also implicated are changes in activity of the sirtuin or SIRT protein family.) When engineered specifically to produce less of the hormone, they don't grow as large, but their life span is 30 to 50 percent longer."